Research Legacy Page

This page outlines the work that students have done to contribute to the overall story.  Because of the background necessary for making a complete document, this page will not be in its complete form until April 2005.

George Nora, M.S. 2000

                 
George was the first graduate student to work in the Hitchcock Research Lab.  George's work was integral in the early phases of the oxadiazinone chemistry development.  George's key contribution was the formation of oxadiazinone and the corresponding oxadiazine-2-thiones. 

David M. Casper, M.S. 2003

From George's initial work in the oxadiazinone synthesis, Dave took the project to the next level by improving the synthesis of the heterocycle so that no chromatography is involved.  With this technical improvement, Dave went on to conduct pilot studies on the asymmetric aldol reaction.  This work was highly successful and is the basis of much of the work that has been done in the Hitchcock Research Group in 2002,2003, and 2004 and into 2005.  Dave also contributed to the development of a synthetic pathway to Nelfinavir. 

Christine Hedberg
 

Laura Buchanan
 

M. Kathyrn Buchanan

Michael D. Squire, M.S. 2003
 

Michael was instrumental in the pushing the envelop of oxadiazinone substitution.  He designed, executed and applied the N₄-bornyl oxadiazinone thereby showing, in part, the scope and limitations of using alkyl groups at the stereochemical "pivot" point of the N₄-position. 

Jessica Speckhart
 

Chelsea West

Chelsea's work included development of the heterocycle synthesis when it was being initially worked out during the 1999 academic year. 

Deanna C. Taylor

Susan Pasquale

Brian Kieth Voelker

Carrie (Stafford) Adams

Carrie's research was primarily involved in the synthesis and development of the oxadiazine-2-thiones.  This work was published in the Journal of  Heterocyclic Chemistry. 

David Kieser
 

Jennifer R. Blackburn, M.S. 2003

Jen's work involved developing a greater understanding of the conformational properties of the pseudoephedrine based oxadiazinone.  Jen also conducted studies in the conjugate addition reactions of oxadiazinones.  This work will hopefully be published this year in the Journal of Organic Chemistry. 

Jeromy T. Bentley, M.S. 2002

Jeromy's work invovled the synthesis of w-hydroxy hydrazones derived from chiral, non-racemic ephedrine and pseudoephedrine.  As of June 2006 this research is being directed towards catalytic asymmetric synthesis.  These compounds may turn out to be effective ligands in the enantioselective addition of diethylzinc (Et₂Zn) to prochiral aldehydes. 

Trisha R. Hoover, M.S. 2003

Trisha worked on the asymmetric aldol reaction of glycolate systems and the alpha halo project which has been taken by Alexandro Dominguez who is working hard to complete this work for publication in the Journal of Organic Chemistry. 

James Burgeson, M.S. 2003

Tana Brady, B. S. 2001

Myra Bolton
 

Joe Davidson, B.S. 2002

Joe's work involved the synthetic development of the oxadiazine-2-thione synthesis using reagents such as carbon disulfide, 1,1'-thiocarbonyldiimidazole (TCDI), or thiophosgene.  This work was published in the Journal of Heterocyclic Chemistry. 

Ross Rubel

Yao (David) Anim-Addo
 

Jesse Wolfe, B.S., 2004
 

Jeremy F. Vaughn, M.S. 2004

Jeremy's work involved showing the asymmetric glycolate aldol reactions were viable with different types of oxadiazinone derivatives. 

If I have forgotten anything or left out any info, then please contact me at Asymmetric Transformations, Inc. and I will make the additions.